IndraLab

Statements



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"Knockdown of USP21 reduced the proliferation of MDA-MB-157 and MDA-MB-231 cells 5 days after siRNA transfection (XREF_FIG)."

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"In addition, ectopic, doxycyclineinducible expression of FOXM1b in MDA-MB-231 cells partially rescued the impaired proliferation caused by USP21 depletion."

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"As a result, siRNA mediated depletion of USP21 inhibits cell proliferation, invasion ability and decreases the CSCs percentage of RCC cell lines."

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"USP21 is upregulated in renal cell carcinoma tissues and cell lines, and depletion of USP21 inhibits cell proliferation and invasion through binding to the IL-8 promoter region and mediating transcriptional initiation 22."

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"Knockdown of USP21 in TNBC cells inhibited cell proliferation, migration and invasion."

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"Several functional experiments, including colony formation analysis and CCK-8 analysis, suggested that overexpression of USP21 promoted cell proliferation and inhibition of USP21 suppressed cell proliferation."

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"USP21 knockdown or overexpression in the DLBCL cell line shows that USP21 promotes cell proliferation."

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"Accordingly, BCR-ABL-mediated signaling and cell proliferation were suppressed in BCR-ABL-positive leukemia cells by the depletion of USP25."

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"Therefore, while depletion of USP21 (and FOXM1) impairs proliferation in each of these cell lines under control conditions, there is a statistically significant decrease in viability when USP21 depletion is combined with paclitaxel treatment."

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"While cell proliferation rates were comparable at early time points examined, we found that USP21 depletion led to dramatically decrease of cell proliferation 6 days after transfection."