IndraLab

Statements

Ubiquitin inhibits OTUB1. 3 / 3
| 3
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"Importantly, ubiquitin variants targeting OTUB1 selectively inhibited OTUB1 mediated cleavage of K48 di-ubiquitin."
28923280
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"Ubv.B1.1 efficiently inhibited OTUB1 catalyzed cleavage of K48‐linked di‐Ub [132]."
24239534
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"Indeed, the inhibitory complex formed by OTUB1 with charged E2 ~ Ub thioester and free ubiquitin also inhibits OTUB1 DUB activity, thus raising the possibility that inhibition of OTUB1 could be an equally important function of the OTUB1-Ub-E2 ~ Ub inhibitory complex."
23955022