IndraLab

Statements

Acetoacetate inhibits NLRP3. 6 / 6
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"It was proved that the Short Chain Fatty Acids (SCFAs) beta-hydroxybutyrate (BHB) and acetoacetate, both elevated during starvation, inhibit the NLRP3 inflammasome."
34104708
reach
"There is evidence that ketone bodies, beta-hydroxybutyrate (BHB), but not acetoacetate (AcAc) or the structurally related SCFAs, butyrate and acetate, suppress activation of the Nlrp3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids XREF_BIBR, XREF_BIBR."
29475132
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"We report that BHB, but neither acetoacetate nor structurally related short chain fatty acids, butyrate and acetate, suppresses activation of the NLRP3 inflammasome in response to several structurally unrelated NLRP3 activators, without impacting NLRC4, AIM2 or non canonical caspase-11 inflammasome activation."
25686106
reach
"It was proved that the Short Chain Fatty Acids (SCFAs) β-hydroxybutyrate (BHB) and acetoacetate, both elevated during starvation, inhibit the NLRP3 inflammasome."
34104708
reach
"It was proved that the Short Chain Fatty Acids (SCFAs) b-hydroxybutyrate (BHB) and acetoacetate, both elevated during starvation, inhibit the NLRP3 inflammasome."
34104708
reach
"A study by Youm et al. showed that the NLRP3 inflammasome activation was inhibited by the ketone body beta-hydroxybutyrate (BHB) but not by acetoacetate or by related short-chain fatty acids butyrate and acetate [XREF_BIBR]."
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