IndraLab

Statements

USP8 binds ESCRT-III complex. 2 / 2
| 2
reach
"Previous studies have shown that the recruitment of USP8/UBPY to the ESCRT-III complex deubiquitinates EGFR and thereby drives EGFR into ILVs, which fuse with lysosomes for further degradation ."
38030597
reach
"Once internalized cargo has been committed for degradation, conjugated ubiquitin must be recycled and removed by endosomal DUBs such as USP8, which also associate with the ESCRT and III complex on late endosomes 8, 18."
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