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Slotoxin inhibits KCNMA1. 4 / 4
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"Here we describe a new scorpion toxin alphaKTx1.11 (slotoxin (SloTx)) that specifically inhibits mammalian MaxiK channels and is capable of differentiating among three types of complexes, alpha, alpha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results are consistent with the fact that SloTx blocks MaxiK channels and the view that the positively charged C-terminal domain is a major component for specific short-range interactions betwee[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Slotoxin blocks the MaxiK pore forming alpha subunit reversibly (K (d) = 1.5 nM)."
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"Thus, we decided to explore whether the smooth muscle beta1 subunit [30] or neuronal beta4 subunit [5] modify the pattern of SloTx blockade of MaxiK channels."
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