IndraLab

Statements

EIF3F is phosphorylated on S46. 6 / 6
| 3 3
rlimsp
"Two different phosphorylation sites have been identified in eIF3f during apoptosis: Ser46 [39] and Thr119 [60]."
23354061
sparser
"Moreover, caspase-processed isoform of the cell division kinase 11 (Cdk11 p46 ) binds and phosphorylates eIF3f at Ser-46 and Thr-119 during apoptosis in A375 melanoma cells, leading to an inhibition of translation ( xref )."
23769948
sparser
"For instance, phosphorylation of eIF3f at Ser46 and Thr119 was shown to enhance its association with the core eIF3 subunits leading to the inhibition of translation during apoptosis [ xref ]."
30401537
rlimsp
"Considering that the phosphorylations on Ser46 and Thr119 have been detected in cells undergoing apoptosis, it has been postulated that eIF3f may be involved in the inhibition of the protein synthesis when phosphorylated, acting as a downstream death executer."
23354061
sparser
"Moreover, caspase-processed isoform of the cell division kinase 11 (Cdk11p46) binds and phosphorylates eIF3f at Ser-46 and Thr-119 during apoptosis in A375 melanoma cells, leading to an inhibition of translation (Shi et al., 2003)."
23769948
rlimsp
"Upon apoptotic stimulation, CDK11p110 is cleaved by caspase 3 to generate a CDKp46 that interacts strongly with the Mov34 domain of eIF3f and phosphorylates it at Ser46 and Thr119."
23354061