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Caspase inhibits CYLD. 1 / 1

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"In cells undergoing apoptosis, cylindromatosis (CYLD) would remove Lys63 linked polyubiquitins from RIPK1 [XREF_BIBR], rendering complex I unstable and allowing RIPK1 to dissociate from the plasma membrane and interact with TRADD dependent complex IIa; in this complex FLIPL and pro caspase 8 form a heterodimeric caspase that cleaves and inactivates RIPK1 (and RIPK3), as well as CYLD, to prevent necroptosis [XREF_BIBR] (XREF_FIG a)."

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IndraLab

Statements

Caspase inhibits CYLD. 1 / 1

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