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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Caspase inhibits CYLD. 1 / 1

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"In cells undergoing apoptosis, cylindromatosis (CYLD) would remove Lys63 linked polyubiquitins from RIPK1 [XREF_BIBR], rendering complex I unstable and allowing RIPK1 to dissociate from the plasma membrane and interact with TRADD dependent complex IIa; in this complex FLIPL and pro caspase 8 form a heterodimeric caspase that cleaves and inactivates RIPK1 (and RIPK3), as well as CYLD, to prevent necroptosis [XREF_BIBR] (XREF_FIG a)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...