IndraLab

Statements

BAP1 activates double-strand break repair. 5 / 5
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"In addition to a potentially critical role for BAP1 inactivation in epigenetic deregulation in ccRCC, BAP1 has been found to promote DNA double-strand break repair by homologous recombination, thereby adding to its tumor suppressor function [XREF_BIBR]."
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"BAP1 protein was reported to form a complex with host cell factor-1 (HCF-1) and promotes DNA double-strand break repair."
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"The literature suggests that BAP1 promotes DNA double-strand break repair and that its loss leads to homologous recombination repair defects, reminiscent of BRCA1/2 deficiency."
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"Although BAP1 stimulates DNA double-strand break repair, whether it functions in nucleotide excision repair (NER) is unknown."
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"BAP1 loss impairs HR and double-strand break repair, promoting error-prone nonhomologous end joining, with consequent genomic instability (XREF_FIG)."
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