IndraLab

Statements

4-aminopyridine inhibits KCNH2. 8 / 8
1 | 6 1
reach
"HERG K + current and ventricular I to are blocked by 4-AP XREF_BIBR, XREF_BIBR."
29720607
reach
"As demonstrated in the experimental data, 4-aminopyridine induced a concentration dependent inhibition of the hERG channel currents."
19915712
reach
"Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine."
12740430
ctd
No evidence text available
19915712
reach
"Although inhibition of hERG by 4-aminopyridine was observed, the clinical relevance of these data needs to be considered."
19915712
reach
"At the two lowest concentrations, 0.1 mM had no effect and inhibition of hERG by 4-aminopyridine 0.3 mM was minimal (8.2 +/- 0.9%; N = 3)."
19915712
reach
"Both K + channel blockers, 4-AP and TEA, significantly inhibited the proliferation of Eag and HERG positive SK-OV-3 cells, confirming data by Zhanping et al., on the A2780 ovarian cancer line [XREF_BIBR]."
21138547
sparser
"Both TEA and 4-AP are non selective K + channel blockers capable of inhibiting Eag and HERG as well as other voltage gated K + channels."
21138547