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USP2 inhibits Hypertrophy. 2 / 2
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"In addition, by comparing the GEO dataset and the mRNA level of USP2 in hypertrophic heart induced by trans-arterial coarctation (TAC), it was determined that the expression of USP2 was downregulated in hypertrophic heart, and the overexpression of USP2 could relieve the cardiac hypertrophy induced by TAC."
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"Altogether, we initially demonstrated that USP2 overexpression suppressed hypertrophy, calcium overload, and mitochondrial dysfunction and increased protein levels of MFN2 via deubiquitination in Ang [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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