IndraLab

Statements

USP18 inhibits EGFR. 3 / 3

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"USP18 mediates deISGylation of BECN1 to promote autophagy and EGFR degradation."

25906440

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"This suggests that depletion of Usp18 inhibited EGFR mRNA translation."

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"Thus, blocking Lys63 ubiquitination of selected target proteins by ISGylation may provide a general mechanism for type I IFN and ISG15 to modulate target activities.Our study demonstrates that USP18 positively regulates autophagy and EGFR degradation by promoting de-ISGylation of BECN1."

25906440

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

USP18 inhibits EGFR. 3 / 3

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