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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

COPS5 bound to TGFB activates transcription, DNA-templated. 1 / 1

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"Jab1 and COPS5 directly binds to Smad4 and degrades it through the proteasome pathway and thus attenuate TGF-beta mediated gene transcription, whereas its degradation of Smad7 results in enhanced TGF-beta signaling effects."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...