IndraLab

Statements

USP3 activates Ubiquitin. 6 / 6
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"Nagy et al. reported that USP3 promotes neuroblastoma cell viability, proliferation, and xenograft tumor growth by cleaving K48‐ and K63‐linked ubiquitin chains of MYCN (Figure 2C, right)."
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"Paradoxically, by removing the bulky ubiquitin chain at the active site, USP3 also increased the accessibility of CHK1 to its substrates."
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"As one of the factors responsible for NSCLC cell proliferation, USP3 may lead to Ub-mediated degradation by targeting RBM4, which is a tumour suppressor gene and a key molecule for RNA splicing (79)."
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"The USP3 protein is a functional ubiquitin specific protease in vitro, and is able to inhibit ubiquitin dependent degradation of both an N-end Rule substrate and abnormal endogenous proteins in yeast."
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"The data relate to the research article " Tight regulation of ubiquitin mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells " (Lancini et al., 2014) XREF_BIBR."
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"Tight regulation of ubiquitin mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells."
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