IndraLab

Statements


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"The data relate to the research article " Tight regulation of ubiquitin mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells " (Lancini et al., 2014) XREF_BIBR."

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"The USP3 protein is a functional ubiquitin specific protease in vitro, and is able to inhibit ubiquitin dependent degradation of both an N-end Rule substrate and abnormal endogenous proteins in yeast."

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"The data relate to the research article " Tight regulation of ubiquitin mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells " (Lancini et al., 2014) [4]."

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"Paradoxically, by removing the bulky ubiquitin chain at the active site, USP3 also increased the accessibility of CHK1 to its substrates."

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"Tight regulation of ubiquitin mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells."