IndraLab

Statements

OTULIN activates apoptotic process. 5 / 5
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"Similarly, OTULIN-deficient HCT116 cells were shown to be sensitized to TNF-induced apoptosis, which could be prevented in the presence of the pan-caspase inhibitor zVAD-fmk (Fig. 4D)."
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"OTULIN deficiency triggers metabolic alterations, apoptosis, and inflammation in the liver."
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"To elucidate the mechanism by which OTULIN promotes resistance to apoptosis in osteosarcoma cells, we conducted immunoprecipitation (IP) analysis of 143B cells utilizing an anti-OTULIN-specific antibody (an anti-IgG antibody was used as a control)."
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"Indeed, OTULIN deficient IECs are shown to die from TNF-induced apoptosis."
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"These data suggest that GPX4 could be a potential target of OTULIN for resistance to cisplatin-induced apoptosis."
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