IndraLab

Statements


USP9Y activates DDX3Y. 4 / 4
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"The AZFa sub-region comprises three candidate genes- DDX3Y (former name DBY), USP9Y and UTY and mutation in these genes leads to absence of spermatogenic cells."

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"Notably, protein expression of DDX3Y decreased by USP9Y silencing was inhibited after MG132 treatment, which indicated that USP9Y prevented DDX3Y degradation by the proteasome in SPC-A1 cells ( Fig. 5[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"In addition to overexpression of Y-chromosome-related transcripts (n = 18), such as USP9Y (FC> 13.1), DDX3Y (FC> 11.3), RPS4Y1 (FC> 9.9), and EIF1AY (FC> 11.8) in males, there was overexpression of CD24 (FC> 5.6) and KCNK1 (FC> 1.5)."

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"We also found that USP9Y overexpression decreased polyubiquitination and increased the half-life of DDX3Y in SPC-A1 cells ( Fig. 5 F)."