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CTNNB1 dephosphorylates CTNNB1 on Y654. 3 / 3
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"As shown in Fig. 3 A, SHP-1 expression markedly inhibited c-src and CA-induced beta-catenin and TCF transcriptional activity.Because SHP-1 can dephosphorylate residues Y86 and Y654 on the beta-catenin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"After treated with ATRA, transcriptional activity of beta-catenin decreased by downregulating phosphorylation of beta-catenin Ser45, Y654 and GSK-3beta Ser9."
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"These results, hence, emphasize that SHP-1 controls beta-catenin expression through to a decrease in the beta-catenin protein stability rather than by a decrease in mRNA levels.Since SHP-1 is able to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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