IndraLab

Statements

UCHL1 activates CDKN2A. 2 / 2
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"UCH-L1 prolongs the half-life of p53 and p14ARF proteins through its deubiquitinase activity and shortens the half-life of MDM2 proteins through ubiquitination, resulting in the inhibition of NPC cell proliferation (67)."
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"The exact mechanism by which UCHL1 regulates tumor development remains uncertain, although recent data suggest that UCHL1 increases the half-life of p53 and p14 ARF, decreases the half-life of Mdm2, and activates the p53 signaling pathway XREF_BIBR, XREF_BIBR."
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