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USP46 activates NRAS-Q61R. 1 / 1
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"Consistently, the depletion of USP46 substantially inhibited cell proliferation of NRAS Q61R-transformed melanocytes in vitro and in vivo (Fig. 5b–d), whereas the depletion of USP46 in cells expressing FLAG-NRAS Q61R-2KR did not exert these effects (Supplementary Fig. 6a–d)."