IndraLab

Statements

PGD activates KCNMA1. 3 / 3
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"Collectively, these results demonstrated that PGD 2 induces a CXCR4 dependent basophil accumulation in SLO, associated with a transient basopenia."
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"As expected, PGD 2, but not another prostaglandin (PGE 2), induced basophil accumulation in SLO, along with their increased IA-IE and CXCR4 expressions."
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"Here, we report that PGD 2 induces a CXCR4 dependent accumulation of basophils in SLO, and that antagonizing PTGDR in vivo in two distinct lupus like mouse models prevented this recruitment in SLO without impacting other cell type populations but the short lived plasma cells."
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