IndraLab

Statements

OSM activates IL6ST. 27 / 32
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"Importantly, OSM induces the dimerization of OSMR with another receptor partner IL6ST."
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"OSM also activates gp130, either via its own OSM receptor (OSMRβ) subunit or via LIFR ( xref )."
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"LIFR and gp130 can be activated by either LIF or OSM, but OSMR and gp130 is activated only by OSM [18]."
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"Stimulation of cells with the interleukin-6 family of cytokines triggers homo- or hetero-dimerization of gp130. The dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. Some of these biological activities of il-6 are also often exerted by other cytokines, i.e. Il-11, lif, osm, cntf, and ct-2."
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"Since the IL-6 family is thought to have the highest degree of functional pleiotropy and redundancy in triggering the health- and disease-related responses of all cytokine families [27], the unique effects of OSM-activated gp130 receptor complexes feature less in the scientific focus of heart diseases."
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"3-5 OSM can also elicit an active heterodimer of gp130 and the OSM receptor (OSMR)."
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"Mechanistically, OSM activates the heterodimeric receptor complex gp130:OSMR [7], resulting in the activation of JAK/STAT [8] and MAPK signaling pathways."
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"Using a dominant-negative LIF mutant (hLIF-05), we showed that in RC cell cultures mouse OSM (mOSM) activates exclusively glycoprotein 130 (gp130)/OSMR."
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"Using a dominant negative LIF mutant (hLIF-05), we showed that in RC cell cultures mouse OSM (mOSM) activates exclusively glycoprotein 130 (gp130)/OSMR."
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"OSM activates a complex of OSM receptor (OSMR) and IL6ST."
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"Mechanistically, OSM activates the heterodimeric receptor complex gp130:OSMR [ xref ], resulting in the activation of JAK/STAT [ xref ] and MAPK signaling pathways."
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"In this study using several gp130 mutants, we investigated requirements for gp130 activation by the cytokines LIF and OSM."
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"Gp130 and OSMR is activated only by OSM, but gp130 and LIFR can be activated by either LIF, OSM or both."
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"Apart from IL-6, other gp130 activators such as LIF, OSM and CNTF can also induce astrogliosis (Damiani and O'Callaghan, 2007; Sriram et al., 2004)."
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"53 As a member of the IL-6 family of cytokines, OSM has homogenous protein sequence and structure as that of other family members.57 Studies in the mouse showed that human OSM activates the heterodimer of LIF receptor B and gp130, as does CNTF.58 59 An increase in STAT3 phosphorylation was localized to Müller cells after intravitreal delivery of OSM in an ONC model, indicating that the neuroprotective effect of OSM on the RGC is medicated by Müller cells."
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"Previous studies have reported that OSM treatment increases gp130 promoter activities and enhances the synthesis of OSMRbeta and gp130, and to a lesser extent, LIFR in various cell lines [40]."
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"Similarly, human OSM only activates gp130 and OSMRbeta and not LIFR in human adipocytes."
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"To investigate whether B14 and B21 monoclonal antibodies (mAbs) inhibit OSM-induced dimerization of OSMR with IL6ST, we immunoprecipitated OSMR-IL6ST heterodimer complex cross-linked after treating with anti-OSMR antibody or control IgG."
34380633
sparser
"Since the IL-6 family is thought to have the highest degree of functional pleiotropy and redundancy in triggering the health- and disease-related responses of all cytokine families [ xref ], the unique effects of OSM-activated gp130 receptor complexes feature less in the scientific focus of heart diseases."
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"50 The observation that LIF and OSM induce a complex of gp130 and RILLIFDeltaII that is as active as the wild-type LIFR complex negates the hypothesis that this CBM is an important dimerization site i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11812136
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"In the AGM culture system, supplementation of OSM, which activates gp130, has been shown to be indispensable in addition to bFGF and SCF [12] ."
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"Gp130 and LIFR can be activated by LIF or OSM, but gp130 and OSMR is activated by OSM only."
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"On the molecular level this usage of OSM from different species results in the stimulation of different receptor complexes : human OSM exclusively binds to the type I gp130 and LIFR system in mouse cells; murine OSM, however, exclusively activates the type II gp130 and OSMR system."
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"Similarly, human OSM only activates gp130 and OSMRβ and not LIFR in human adipocytes."
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"However, only OSM activates the OSM receptor (OSMR) and gp130 complex."
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"OSM can induce the formation of a dimer of gp130 with LIFR or the related protein, oncostatin M receptor."
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"Oncostatin M. Oncostatin M (OSM) is an inflammatory cytokine that also belongs to the family of gp130 related cytokines, and as such, OSM stimulates transmembrane signaling by binding and activating either of two receptor complexes : (1) gp130 and LIFR (leukemia inhibitor factor receptor) heterodimers, and (2) gp130 and OSM receptor (OSMR)."
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