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OTUB1 increases the amount of HIF1. 2 / 2
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"In analyzing the role of OTUB1 in the hypoxia signaling pathway, we examined the effect of OTUB1 on HIF-1α protein level and found that OTUB1 could upregulate the protein level of HIF-1α (Fig. S4E-G, I)."
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"Furthermore, ectopic expression of OTUB1 also increased protein levels of co-transfected HIF-1α-DM (in which two Proline residues [P402 and P564] are mutated to Alanine residues) and HIF-1α-TM (in which two Proline residues [P402 and P564] and one Asparagine residue [N803] is mutated to Alanine residue) (Fig. 5D, E), suggesting that the stabilization of HIF-1α protein by OTUB1 might be independent of hydroxylation mediated by PHDs and FIH."
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