IndraLab

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COPS6 activates AKT. 7 / 8
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reach
"Our mechanistic studies of CSN6 mediated 14-3-3sigma downregulation explains how CSN6 can activate Akt in our proposed model (XREF_FIG)."

sparser
"Our mechanistic studies of CSN6-mediated 14-3-3σ downregulation explains how CSN6 can activate Akt in our proposed model ( xref )."

reach
"The observation that CSN6 increases the activity of Akt (XREF_FIG) is very intriguing."

reach
"Consistent with this, we found that CSN6 can downregulate the expression of 14-3-3sigma and lead to Akt activation."

sparser
"In addition to demonstrating amplification of the CSN6 gene locus at 7q22.1 in human mammary tumors, xref they report that AKT phosphorylation at Ser60 stabilizes CSN6. xref Interestingly, by promoting 14–3-3σ degradation through stabilization of its E3-ligase COP1, CSN6 can activate AKT to create a self-propelling positive feedback loop xref ( xref )."

reach
"Because 14-3-3sigma suppresses Akt activity, we first examined whether knockdown of CSN6 could suppress Akt activity and inhibit Akt mediated cell survival."

reach
"XREF_BIBR Interestingly, by promoting 14-3-3sigma degradation through stabilization of its E3-ligase COP1, CSN6 can activate AKT to create a self propelling positive feedback loop XREF_BIBR (XREF_FIG)."