IndraLab

Statements

COPS6 activates AKT. 7 / 8
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"Our mechanistic studies of CSN6 mediated 14-3-3sigma downregulation explains how CSN6 can activate Akt in our proposed model (XREF_FIG)."
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"Our mechanistic studies of CSN6-mediated 14-3-3σ downregulation explains how CSN6 can activate Akt in our proposed model ( xref )."
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"The observation that CSN6 increases the activity of Akt (XREF_FIG) is very intriguing."
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"Consistent with this, we found that CSN6 can downregulate the expression of 14-3-3sigma and lead to Akt activation."
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"In addition to demonstrating amplification of the CSN6 gene locus at 7q22.1 in human mammary tumors, xref they report that AKT phosphorylation at Ser60 stabilizes CSN6. xref Interestingly, by promoting 14–3-3σ degradation through stabilization of its E3-ligase COP1, CSN6 can activate AKT to create a self-propelling positive feedback loop xref ( xref )."
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"Because 14-3-3sigma suppresses Akt activity, we first examined whether knockdown of CSN6 could suppress Akt activity and inhibit Akt mediated cell survival."
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"XREF_BIBR Interestingly, by promoting 14-3-3sigma degradation through stabilization of its E3-ligase COP1, CSN6 can activate AKT to create a self propelling positive feedback loop XREF_BIBR (XREF_FIG)."
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