IndraLab

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SCN8A activates SH2B2. 3 / 3
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"We found that RT cells of Scn8a + /- mice produced fewer APs in both tonic and burst firing modes (XREF_SUPPLEMENTARY)."
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"In myelinated nerves of mammals, Nav1.6 voltage-gated Na channels are highly clustered at NRs and are believed to drive nodal membrane depolarization to generate APs at the NRs."
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"A recent study reported that the loss of the sodium channel Scn8a (NaV1.6) from TRN cells preferentially impaired the excitation of action potentials (APs) and led to absence seizures [14]."
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