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DNMT1 inhibits USP7. 2 / 3
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"Thus , our data revealed that loss of USP7 variably reduced DNMT1 and UHRF1 protein stability , presumably due to its deubiquitinase activity toward DNMT1 and UHRF1 as reported previously38-41 ."
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"Moreover, DNA methyltransferase 1 (DNMT1) can catalyze the methyl group transfer to the CpG island of DNA to mediate DNA methylation and USP7 can induce the deubiquitination of DNMT1, while acetylation of DNMT1 disrupts the function of USP7 and leads to DNMT1 degradation (Cheng et al., 2015)."
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