IndraLab

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Glucose activates UCHL1. 4 / 4
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"Results demonstrated that HG induced upregulation of UCH-L1 and activation of the Wnt and beta-catenin signaling pathway in podocytes."
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"To provide the intrinsic mechanism of UCH-L1 upregulation in HG stimulated podocytes, podocyte cells were treated with HG for 24 or 48 h, after preincubated with or without recombinant Dickkopf-1 (DKK1) protein, a secreted Wnt antagonist that can specially block the canonical Wnt signaling [XREF_BIBR]."
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"However, it is unknown whether the canonical Wnt and beta-catenin signaling mediates high glucose induced upregulation of UCH-L1 in podocytes."
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"In this experiment, findings demonstrated that HG significantly upregulated UCH-L1 in mouse podocyte cells (XREF_FIG, p < 0.05)."
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