IndraLab

Statements

CAMP-dependent phosphorylates KCNQ1. 3 / 3
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"Few pathogenic variants have been reported in this gene, the AP duration is prolonged due to a reduction of the cAMP-dependent phosphorylation of Kv7.1, and reduction in cAMP stimulation response occurs. xref "
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"These results confirmed the key role of the AO state in modulating the cAMP-dependent phosphorylation of both KCNQ1 and I Ks channels."
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"Loss of this scaffold decreases cAMP-dependent PKA phosphorylation of KCNQ1, eliminates the functional response by I Ks , and prolongs the action potential [ xref ]."
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