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Lipopolysaccharide inhibits TRAF6. 21 / 21
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"We found that while treatment of 2muM caerulein alone increased the levels of Traf6 expression significantly, the combination of 2muM caerulein and 1muM LPS suppressed the activation of Traf6 by caerulein (XREF_FIG)."
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"Therefore, we drew the conclusion that LPS down-regulated miR-132 and miR-132 attenuated LPS induced inflammatory cell injury by targeting TRAF6, along with the inhibition of the NF-kappaB and MEK and ERK pathways."
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"XREF_BIBR Notably, TRAF6 is not degraded by LPS stimulation suggesting that the ubiquitin editing function of A20 may be specific for RIP1."
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"Western blot experiments revealed that LPS alone did not result in reduced TRAF6 levels ( most likely due to the re-synthesis of TRAF6 , as the effects of LPS were only visible in the presence of Anisomycin ) , and LPS-triggered TRAF6 decay was decreased in TRAF6 P-mim cells ( Figure 4A ) ."
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"Interestingly, LPS stimulated splenic B cell proliferation was inhibited in TRAF6 deficient mice."
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"Overall, the present study indicated that miR-490-3p overexpression significantly inhibited LPS induced ALI and inflammatory responses by restricting the IRAK1 and TRAF6 pathway."
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"This finding was confirmed in an in vitro model of LPS-stimulated H9c2 cells, where miR-146a improved cell viability and reduced apoptosis by suppressing IRAK1 and TRAF6, thereby negatively regulating the NFκB pathway [63]."
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"MiR-643 inhibits lipopolysaccharide induced endometritis progression by targeting TRAF6."
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"Western blot experiments revealed that LPS alone did not result in reduced TRAF6 levels (most likely due to the re-synthesis of TRAF6, as the effects of LPS were only visible in the presence of Anisomycin), and LPS-triggered TRAF6 decay was decreased in TRAF6 P-mim cells (Figure 4A)."
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"MicroRNA-490-3p inhibits inflammatory responses in LPS induced acute lung injury of neonatal rats by suppressing the IRAK1 and TRAF6 pathway."
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"Upregulated miR-20-1 and miR-101a inhibit LPS-induced inflammatory cytokines production by targeting TNF receptor-associated factor 6 (TRAF6), thus avoiding excessive inflammation."
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"miR-140 regulates inflammatory cytokine secretion of LPS induced colorectal cancer cells by targeting TRAF6."
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"In addition, miR-146a-5p mimic blocked LPS induced TRAF6 dependent c-Jun N-terminal kinase (JNK) and Smad2 activation as well as alpha-SMA production."
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"To examine whether LPS played a direct role in the inhibition of Traf6 expression, cells were treated with caerulein or LPS alone, or both in different combinations for 48h, and collected for western blotting analysis."
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"Retraction : " MicroRNA-132 attenuates LPS induced inflammatory injury by targeting TRAF6 in neuronal cell line HT-22, " by Yang-Fei Ji, Dan Wang, Yan-Ru Liu, Xing-Rong Ma, Hong Lu, Bo-Ai Zhang, J Cell Biochem."
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"In addition, miR-146a-5p mimic blocked LPS-induced TRAF6 upregulation, as well as LPS-induced c-Jun N-terminal kinase (JNK) activation and chemokine CCL2 expression in astrocytes."
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"17 For instance, LPS inducible miR-146a downregulates TNF receptor associated factor 6 (TRAF6), interleukin-1 receptor associated kinase 1 (IRAK1) and tumor necrosis factor alpha (TNF-alpha) that renders cells refractive to further stimuli, while miR-21 regulates expression of programmed cell death 4 (PDCD4), a proinflammatory protein which induces NF-kappaB and IL-6 production."
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"Our recent reports have shown that miR-146a is critical for LPS induced tolerance [XREF_BIBR] and cross-tolerance [XREF_BIBR] in monocytic cells by repressing IRAK1 and TRAF6 adaptor molecules."
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"LPS also downregulated TRAF-6 , an important mediator of TLR , TNF , and IRAK complex signaling and IRF2 , a competitive inhibitor of IRF1 ."
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"In another animal research, upregulation of miR-146a inhibited IL-6, IL-1β, and TNF-α secretion in ALI model induced by LPS via suppressing TRAF-6 and IRAK-1 [43]."
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"MicroRNA-132 attenuates LPS induced inflammatory injury by targeting TRAF6 in neuronal cell line HT-22."
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