IndraLab

Statements

Lanosterol inhibits KCNH2. 7 / 7
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"High level of lanosterol promotes the degradation of Erg1."
25003069
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"Therefore, it is urgent to abolish the regulation of ERG1 so as to increase the precursor supply for PT production.It was reported that ERG1 might be negatively regulated by lanosterol [20]."
37143155
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"However, it was reported that the over-expression of ERG1 could increase the level of lanosterol [17, 23], which would accelerate the degradation of ERG1 to impede the epoxidation of squalene."
37143155
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"However, in the earlier study [20], lanosterol was found to accelerate the degradation of ERG1."
37143155
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"To prevent the accumulation of free toxic sterol, lanosterol accumulation induces the degradation of Erg1 protein via the endoplasmic reticulum‐associated protein degradation pathway (Foresti et al., 2013), which in turn has been described to be activated in response to iron deficiency (Seo et al., 2008)."
35837730
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"Erg11 function is likely to decrease due to the drop in heme levels that occurs when iron is scarce, and the subsequent lanosterol accumulation may inhibit Erg1 [9,65]."
32679672
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"Therefore, lanosterol accumulation induced by fluconazole treatment stimulates Doa10 dependent degradation of Erg1."
23898401