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Lanosterol inhibits KCNH2. 4 / 4
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"To prevent the accumulation of free toxic sterol, lanosterol accumulation induces the degradation of Erg1 protein via the endoplasmic reticulum‐associated protein degradation pathway (Foresti et al., 2013), which in turn has been described to be activated in response to iron deficiency (Seo et al., 2008)."
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"High level of lanosterol promotes the degradation of Erg1."
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"Erg11 function is likely to decrease due to the drop in heme levels that occurs when iron is scarce, and the subsequent lanosterol accumulation may inhibit Erg1 [9,65]."
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"Therefore, lanosterol accumulation induced by fluconazole treatment stimulates Doa10 dependent degradation of Erg1."
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