IndraLab

Statements

S100A7 activates COPS5. 7 / 8
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"Psoriasin (S100A7), a small calcium binding protein that is highly expressed in early breast cancer, enhances Jab1 and CSN5 activity and promotes tumorigenesis [XREF_BIBR, XREF_BIBR]."
20955608
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"Moreover, Psoriasin (S100A7), a small calcium binding protein, enhances Jab1 and COPS5 activity as well as AP-1 activity, and promotes tumorigenesis."
29535627
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"The over expression of psoriasin in MDA-MB-231 breast cancer cells was shown to increase nuclear Jab1 activity and enhance tumorigenesis in vivo in nude mice [XREF_BIBR]."
17986321
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"Overexpression of psoriasin increases nuclear Jab1 and CSN5 activity, resulting in increased AP-1 activity and reduced p27 expression [XREF_BIBR]."
20955608
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"Mechanistically, S100A7 enhances survival of breast cancer cells by binding to c-Jun activation domain binding protein 1 (Jab1) and increasing activity of NF-kappaB and p-Akt [XREF_BIBR]."
28212564
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"The interaction of S100A7 with Jab1 appears to cause a cellular redistribution of Jab1, resulting in an accumulation in the nucleus [XREF_BIBR]."
15217486
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"We previously observed that expression of S100A7 induces a relative increase in nuclear Jab1 in a breast cell line, and a concurrent reduction in p27 kip1 protein [XREF_BIBR]."
15217497