IndraLab

Statements

BAP1 activates SP1. 4 / 4
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"Therefore, BAP1 was involved in ODN-mediated Sp1 stabilization and might be a potential target for cancer therapy in drug development."
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"Mitochondrial ROS scavengers prevented DNA damage, BAP1-mediated Sp1 stabilization, and Bax upregulation by ODN."
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"BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation."
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"ODN-induced Bax upregulation was regulated by Sp1 stabilization, which was modulated by BAP1-dependent deubiquitination mediated by the C-terminal domain of p53."
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