IndraLab

Statements

UCHL3 activates Neoplasms. 16 / 16
| 16
reach
"Overexpression of UCHL3 promotes cell growth, colony formation, tumor formation, and tumor stem-like properties."
32546741
reach
"Furthermore, we demonstrated that overexpression of GNG12 could restore the tumor inhibition effect caused by UCHL3 knock down, and UCHL3-GNG12 axis promote colon cancer progression via the NF-κB signal pathway."
38187053
reach
"GSK3β and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer."
38664501
reach
"Finally, UCHL3 functions to promote tumor growth and lung cancer stem-like properties through AhR.Disorder in the deubiquitination process is usually related to tumorigenesis."
32546741
reach
"In this study, we showed that UCHL3 overexpression increased tumor stem-like properties."
32546741
reach
"Importantly, stable knockdown of UCHL3 suppressed tumor growth from H358 cells and inhibited tumor stem-like properties."
32546741
reach
"UCHL3 promoted tumor stem-like properties through stabilization of AhR."
37830596
reach
"Additionally, UCHL3 and EEF1A1 enhance the growth capacity of subcutaneous tumors in nude mice."
38965582
reach
"Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) has been reported to promote diverse tumors, but little is known about its role in HCC."
36969045
reach
"The mechanism by which UCHL3 promotes tumor stem-like properties through AhR requires further investigation.In conclusion, UCHL3 is an AhR DUB that promotes lung cancer proliferation, tumor growth and tumor stem-like properties through stabilizing AhR by its deubiquitination."
32546741
reach
"Therefore, we propose that the inhibition of UCH-L3 activity after anti-cancer therapy could suppress tumor remodeling and metastasis, providing a new strategy to improve the prognosis of gastric cancer patients."
37460253
reach
"Compared with the injection of vector-transfected A549 cells, injection of UCHL3-overexpressing A549 cells significantly increased tumor size, volume, and weight after 1 month of growth (Fig. 2l–n), while the overall body weight was maintained (Supplementary Fig. S2c)."
32546741
reach
"Our data demonstrated the tumor-promoting function of UCHL3 in bladder cancer, suggesting that targeting UCHL3 might be a potential approach for preventing bladder tumorigenesis and progression.Previously, UCHL3 has been found to be robustly expressed in epithelial ovarian cancer and related to intra-abdominal metastases [29]."
37740194
reach
"The observation of the growth volume and weight of tumors in nude mice indicates that UCHL3 significantly promoted the tumor growth of HCC cells (Fig. 1I-J)."
38965582
reach
"UCHL3 promotes tumor stem-like properties through AhR."
32546741
reach
"In summary, our findings revealed that AhR plays a critical role in maintaining the stem-like properties of cells overexpressing UCHL3, confirming that UCHL3 promotes tumor stem-like properties through stabilizing AhR."
32546741