IndraLab

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UCHL3 activates Neoplasms. 16 / 16
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"In this study, we showed that UCHL3 overexpression increased tumor stem-like properties."
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"Importantly, stable knockdown of UCHL3 suppressed tumor growth from H358 cells and inhibited tumor stem-like properties."
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"UCHL3 promoted tumor stem-like properties through stabilization of AhR."
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"Additionally, UCHL3 and EEF1A1 enhance the growth capacity of subcutaneous tumors in nude mice."
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"GSK3β and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer."
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"Finally, UCHL3 functions to promote tumor growth and lung cancer stem-like properties through AhR.Disorder in the deubiquitination process is usually related to tumorigenesis."
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"Compared with the injection of vector-transfected A549 cells, injection of UCHL3-overexpressing A549 cells significantly increased tumor size, volume, and weight after 1 month of growth (Fig. 2l–n), while the overall body weight was maintained (Supplementary Fig. S2c)."
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"Our data demonstrated the tumor-promoting function of UCHL3 in bladder cancer, suggesting that targeting UCHL3 might be a potential approach for preventing bladder tumorigenesis and progression.Previously, UCHL3 has been found to be robustly expressed in epithelial ovarian cancer and related to intra-abdominal metastases [29]."
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"Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) has been reported to promote diverse tumors, but little is known about its role in HCC."
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"The mechanism by which UCHL3 promotes tumor stem-like properties through AhR requires further investigation.In conclusion, UCHL3 is an AhR DUB that promotes lung cancer proliferation, tumor growth and tumor stem-like properties through stabilizing AhR by its deubiquitination."
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"Overexpression of UCHL3 promotes cell growth, colony formation, tumor formation, and tumor stem-like properties."
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"Furthermore, we demonstrated that overexpression of GNG12 could restore the tumor inhibition effect caused by UCHL3 knock down, and UCHL3-GNG12 axis promote colon cancer progression via the NF-κB signal pathway."
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"The observation of the growth volume and weight of tumors in nude mice indicates that UCHL3 significantly promoted the tumor growth of HCC cells (Fig. 1I-J)."
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"UCHL3 promotes tumor stem-like properties through AhR."
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"Therefore, we propose that the inhibition of UCH-L3 activity after anti-cancer therapy could suppress tumor remodeling and metastasis, providing a new strategy to improve the prognosis of gastric cancer patients."
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"In summary, our findings revealed that AhR plays a critical role in maintaining the stem-like properties of cells overexpressing UCHL3, confirming that UCHL3 promotes tumor stem-like properties through stabilizing AhR."
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