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USP49 increases the amount of SIRT1. 4 / 4
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"We further observed that IGF2BP3 overexpression enhanced SIRT1 protein level which was reversed by USP49 knockdown (Figure 7L)."
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"As USP49 serves as a deubiquitinating enzyme, 25 we speculated whether USP49 positively regulated SIRT1 protein level by protecting SIRT1 from proteasome‐dependent degradation."
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"In addition, IGF2BP3 overexpression enhanced SIRT1 protein level which was reversed by USP49 knockdown."
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"Impressively, USP49 silencing decreased SIRT1 protein level in Y‐79/CBP cells; moreover, the decrease in SIRT1 protein level could be reversed by the addition of proteasome inhibitor MG‐132 (Figure 5E), indicating SIRT1 may be degraded in a ubiquitin‐proteasome manner."
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