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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 bound to MIF activates TP53. 2 / 2

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"The interaction of MIF and p53 promotes the association of p53 with Mdm2 and thus leading to the ubiquitination of p53 and its proteasome mediated degradation."

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"Conversely, the HIF-1alpha target MIF can bind to p53 directly and inhibit many p53 dependent responses, senescence included."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...