IndraLab

Statements

TNF leads to the deubiquitination of COPS5. 2 / 2
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"Not only epidermal growth factor (EGF)-mediated glycosylation, which could inactivate GSK3beta, but also COP9 signalosome 5 (CSN5)-mediated deubiquitination induced by TNF-alpha, stabilized PD-L1 expression on tumor cells [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Epidermal growth factor (EGF)-mediated glycosylation inactivates GSK3beta [XREF_BIBR - XREF_BIBR], while TNF-alpha induces COP9 signalosome 5 (CSN5)-mediated deubiquitination [XREF_BIBR], both of which lead to stabilization of PD-L1protein in tumor cells."
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