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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TNF leads to the deubiquitination of COPS5. 2 / 2

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"Not only epidermal growth factor (EGF)-mediated glycosylation, which could inactivate GSK3beta, but also COP9 signalosome 5 (CSN5)-mediated deubiquitination induced by TNF-alpha, stabilized PD-L1 expression on tumor cells [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

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"Epidermal growth factor (EGF)-mediated glycosylation inactivates GSK3beta [XREF_BIBR - XREF_BIBR], while TNF-alpha induces COP9 signalosome 5 (CSN5)-mediated deubiquitination [XREF_BIBR], both of which lead to stabilization of PD-L1protein in tumor cells."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...