IndraLab

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"We conclude that SCA6 pathogenesis may be associated with the CTF, normally found in the cytoplasm, being aggregated in the cytoplasm and additionally distributed in the nucleus."

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"There is scarce literature on this topic, Takahashi et al. ( xref ) uncovered that in spinocerebellar ataxia type 6 the aggregation of α1A voltage-gated calcium channel C-terminal fragment (Cav2.1-CTF) in the cytoplasm can cause cell death."