IndraLab

Statements

Butyric acid inhibits NLRP3. 10 / 10
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"There is evidence that ketone bodies, beta-hydroxybutyrate (BHB), but not acetoacetate (AcAc) or the structurally related SCFAs, butyrate and acetate, suppress activation of the Nlrp3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids XREF_BIBR, XREF_BIBR."
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"In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes."
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"We report that BHB, but neither acetoacetate nor structurally related short chain fatty acids, butyrate and acetate, suppresses activation of the NLRP3 inflammasome in response to several structurally unrelated NLRP3 activators, without impacting NLRC4, AIM2 or non canonical caspase-11 inflammasome activation."
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"Sodium butyrate has a similar chemical structure to HBA and also has been reported to inhibit the NLRP3 pathway [XREF_BIBR]."
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"In colon, butyrate inhibited NLRP3 inflammasome activation via GPR109A."
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"Conclusions : Sodium butyrate can inhibit the activation of NLRP3 inflammasome and decrease the production of IL-1beta and IL-18 in intestinal mucosa of severe scald mice, which protects the intestinal barrier function by alleviating the alteration of tight junction protein expression and localization."
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"Sodium Butyrate and beta-Hydroxybutyric Acid Topical Treatment Inhibits Activation of NLRP3 Inflammasome in Alkali Injured Corneas."
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"Recently the ketone body, beta-hydroxy butyrate (BHB), was shown to efficiently inhibit the NLRP3 inflammasome in macrophages, and in vivo models of inflammatory disease."
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"A study by Youm et al. showed that the NLRP3 inflammasome activation was inhibited by the ketone body beta-hydroxybutyrate (BHB) but not by acetoacetate or by related short-chain fatty acids butyrate and acetate [XREF_BIBR]."
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"For example, Wang et al. reported that sodium butyrate treatment can efficiently inhibit Nlrp3 inflammasome activation and thereby inhibits obesity induced inflammation, indicating that NaB might be a potential anti-inflammatory agent for obesity in db/db mice XREF_BIBR."
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