IndraLab

Statements

USP15 increases the amount of SMAD2. 3 / 3
| 3
reach
"Similarly, ectopic expression of USP15 and SMURF2 C/A did not enhance p-SMAD2 levels compared with either construct alone (XREF_FIG)."
26435193
reach
"Results:. The authors demonstrated that USP15 knockdown significantly inhibited the proliferation, migration, and invasion of hypertrophic scar-derived fibroblasts in vitro and down-regulated the expression of TbetaRI, Smad2, Smad3, alpha-SMA, COL1, and COL3; in addition, USP15 overexpression showed the opposite trends (p < 0.05)."
34546211
reach
"Quantitative real-time polymerase chain reaction and Western blot analysis indicated that USP15 knockdown significantly reduced the mRNA and protein expression levels of TβRI, Smad2, and Smad3 and the fibrosis markers α-SMA, COL1, and COL3; USP15 overexpression showed the opposite trends."
34546211