IndraLab

Statements

CTNNB1 binds CTNNB1. 23 / 53
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"Extent of β-catenin nuclear localization was not associated with specific CTNNB1 gene mutation, tumor grade, presence of non-endometrioid component, or specific concurrent gene mutations in the tumor."
29795437
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"These different subtypes of ovarian cancer are associated with different molecular characteristics: high grade serous cancers typically contain TP53 mutations [ xref , xref ], low grade serous carcinomas often have RAS-RAF pathway activation and mutations in the KRAS and BRAF genes [ xref ], low-grade endometrioid cancers are associated with mutations in the beta-catenin gene, CTNNB1 [ xref ], and mucinous cancers frequently have mutations in KRAS [ xref ]."
18208621
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"Although somatic mutation of CTNNB1 is rare in BC [ xref , xref ], mounting evidences have revealed that the somatic mutations in CTNNB1 are often associated with the upregulation of β-catenin and the pathogenesis of endometrioid-type of endometrial cancer and ovarian cancer [ xref , xref ]."
26285011
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"Although mutation of CTNNB1 is rare in BC [ xref ], mounting evidence has revealed that the mutations in CTNNB1 are often associated with an upregulation of β-catenin and the pathogenesis of endometrial cancer and ovarian cancer [ xref ]."
30181805
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"Mutation in exon 3 of CTNNB1 gene is classically associated with translocation of the β-catenin protein from the membrane to the nucleus and activation of Wnt/β-catenin signaling ( xref , xref )."
30886832
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"Underlining this similarity in molecular taxonomy, WHV-induced HCC was negatively correlated with the CTNNB1 subclass ( xref ) which is also associated with mutations in the β-catenin gene ( xref )."
22431061
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"The impairment of β-catenin signaling in Dox-treated HuH6sh CTNNB1 cells was associated with a substantial cell growth defect when cells were seeded at very low density (Additional file xref : Figure S1-A), whereas cell growth was not significantly affected when cells were seeded at medium density (Additional file xref : Figure S1-B)."
26715116
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"Beta-catenin mutations are associated with cytoplasmic accumulation of free beta-catenin with subsequent nuclear translocation, thus resulting in nuclear expression pattern."
23319036
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"Inhibitor of β-catenin and TCF (ICAT) is an intracellular protein that inhibits the interaction of β-catenin and TCF through binding to the armadillo repeats of β-catenin."
28752488
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"Β-Catenin upregulation is associated with a strong accumulation of β-catenin in the host nuclei suggesting that a transcriptionally active bulk of β-catenin was produced ( xref )."
30320549
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"Furthermore, the reduced level of β-catenin was associated with an increase in phospho-β-catenin."
20103596
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"12-15 Although it appears logical that EC with mutations in exon 3 of CTNNB1 should be associated with abnormal cytoplasmic and nuclear β-catenin immunostaining, the fact is that an abnormal β-cateni[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11957146
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"Importantly, an increased β-catenin level in thyroid tumors ofThrb PV/PV mice is associated with an increase in phosphorylated β-catenin (serine 552), accompanied by increased expression of β-catenin downstream target genes, cyclin D1, c-myc, and matrix metalloprotease (MMP)-1."
22507269
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"14,16–18,20,53,54 Mutations in CTNNB1 and other genes involved in the same pathway are associated with abnormal nuclear beta-catenin accumulation."
15668893
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"MM cell lines have been shown to respond to the Wnt ligand Wnt3A, the GSK3β-inhibitor lithium chloride, and an active mutant form of β-catenin with significantly increased proliferation and higher levels of non-phosphorylated nuclear β-catenin."
25228654
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"However, increase in nuclear levels of the N-terminally dephosphorylated form of β-catenin, Active β-Catenin (ABC), is a significant component that constitutes the key oncogenic step [ xref ]."
31258833
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"In order to determine whether the forced expression of β-catenin reproduced the induction of melanogenesis observed after molecular or pharmacological inhibition of GSK3β, we transiently transfected B[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18602000
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"Mounting evidence have also revealed that the somatic mutations in CTNNB1 are often associated with the up-regulation of β-catenin and the pathogenesis of multiple tumors [ xref , xref ]."
28963373
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"We also examined the levels of key proteins involved in the cell cycle pathway (Cyclin D1:CCND1, Cyclin Dependent Kinase 1:CDK1, Cyclin Dependent Kinase 2:CDK2, Tumor Protein p53:TP53 and Catenin Beta 1:CTNNB1) at 24 and 48 h after CKI treatment previously shown to have altered transcript expression by CKI (Fig.  xref b)."
30678652
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"Fbw1 is a type of F-box protein that is a component of the ubiquitin ligase for β-catenin that associates with β-catenin phosphorylated by casein kinase-1α and GSK-3β resulting in ubiquitination and degradation of β-catenin [ xref , xref ]."
29435196
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"In a bone marrow transplantation model, the interaction between β-catenin and p-β-catenin (Tyr654) is detectable in mice transplanted with p210 BCR/ABL, but not the mutant."
23950177
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"Β-Catenin phosphorylation at sites Ser552 and Ser675 has been associated with enhanced β-catenin stabilization and signaling activity ( xref )."
23474484
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"HAs with activating mutations in the CTNNB1 gene encoding β-catenin with mutations in exon 3 of the CTNNB1 gene encoding β-catenin (HA-B ex3 ) are associated with a high risk of malignant transformation."
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