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"In the model mice, we found a close relationship between the IAV induced ALI and the level and activity of IRF7 in local infectious sites, and also found that the reduced IRF7 level or activity in lungs of the mice treated with IRF7-rODN M1 led to the decreased mRNA levels of Ifna genes, the reduced neutrophil infiltration in the lungs and the prolonged survivals of the mice."