IndraLab

Statements

Mangiferin inhibits RELA. 10 / 13
3 | 10
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"Additionally, mangiferin prevented the STAT3 as well as NF-kappaBp65 signaling pathway activation in the cytosol, which resulted in the anti-inflammatory cytokines being upregulated, whereas, the pro inflammatory cytokines were downregulated."
33389907
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"Mangiferin also reduced the nuclear entrance of NF-kB p65."
38137424
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"Mangiferin may inhibit the activity of PLA2 by regulating CASP3, PTGS2, TNF, and RELA, which interact with PLA2G2A in glycerophospholipid metabolism via TNF, HIF-1, and TLR/MAPK/NF-κB signaling cascad[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37044004
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"Increased expression and distribution of EGF, FGF, TGF-beta, VEGF, PI3K, MMP and Nrf2 and decreased expression and distribution of TNFalpha and NF-kappaB p65 were observed in diabetic wound treated with topical mangiferin."
32013660
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"Mangiferin significantly reduced the nuclear penetration of NF-kappaB p65, however, there were no changes in the expression of other survival signals, such as extracellular signal regulated kinase 1/2, protein kinase B and p38 mitogen activated protein kinase."
33435313
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"The mangiferin administration significantly decreased the relative expression of NF-κB p65 mRNA in liver tissues compared with the DM group ( P < 0.001), and similar pharmacological effects were found[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37044004
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"This effect could be related with previous reports that mangiferin inhibits c-rel and Rel-A which interact with intracellular Ca 2+ -loaded calmodulin [36] ."
16846844
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"On the other hand, an essential transcriptional inhibitor of Nrf2, the NF-kB p65 subunit has been proven to be reduced by mangiferin in streptozotocin-induced diabetic rats ( Gao et al., 2022 ; Zhu et[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36332683
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"Mangiferin (MF) can reduce NF-κB p65, block NF-κB signaling pathway and protect the liver from post-intestinal I/R damage (El-Sayyad et al., 2017)."
35694264
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"Mangiferin treatment markedly reduced the NF-kappaB p65 activation in the colon."
25194678