IndraLab

Statements

Kynurenic acid inhibits NLRP3. 4 / 4
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"Kynurenic acid was shown to be elevated in inflammatory diseases and DSS-induced UC mice ( Xu et al., 2022 ; Zhao et al., 2022 ), and the kynurenic acid/tryptophan ratio was positively correlated with[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Kynurenic acid induces autophagy-dependent degradation of NLRP3, thereby suppressing the activation of NLRP3 inflammasome against CSDS [140] ."
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"In cultured Bone marrow-derived macrophages, kynurenic acid suppresses the activation of the NLRP3 inflammasome in macrophages, which reduces the production of pro-inflammatory cytokines such as IL-1β (113)."
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"Kynurenic acid and GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress."
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