IndraLab

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USP22 activates BCL2. 2 / 2

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"The downregulation of USP1, USP8 and USP22 through their respective siRNA decreased Bcl-2 protein, as shown by western blot analysis."

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"Further analyses showed that USP22 silencing in HepG2 cells decreased the Bcl-2 and Bax ratio and enhanced the release of cytochrome c into the cytoplasm, suggesting the initiation of mitochondrial mediated apoptosis."

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IndraLab

Statements

USP22 activates BCL2. 2 / 2

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