IndraLab

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Kinase-active CCND1 bound to CDK4 phosphorylates RB1. 2 / 2

2 |

"The primary substrates of CDK4/6 and CDK2 in G1 progression are the members of the retinoblastoma protein family RB,p107 and p130 The activity of the RB proteins is modulated by sequential phosphorylation by CDK4/6cyclinD and CDK2cyclinE complexes"

11902577

➶

bel

"In normal G1 progression, the Cyclin D1/CDK4 kinase phosphorylates RB, triggers disruption of the RB/ E2F complex, and frees E2F to activate genes that are necessary for S-phase progression."

15225871

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IndraLab

Statements

Kinase-active CCND1 bound to CDK4 phosphorylates RB1. 2 / 2

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