IndraLab

Statements

SIAH2 leads to the ubiquitination of USP19. 2 / 2
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sparser
"SIAH2 binds to USP19 and promotes USP19 ubiquitylation and proteasome‐dependent degradation xref ; then, the hypothesis of a causal link between SIAH2 and USP19 in cardiomyocyte hypertrophy was established: Decreased transcription of SIAH2 during hypertrophic progress led to less degradation of USP19, and this mechanism partially accounted for USP19 elevation."
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reach
"Here we report that USP19 interacts with the ubiquitin ligases SIAH1 and SIAH2, which promote USP19 ubiquitylation and degradation by the proteasome."
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