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Lipopolysaccharide inhibits NFKB1. 39 / 39
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"We observed significantly diminished LPS induced NF-kappaB p50 and p65 dimer translocation in the cells pretreated with 10mM metformin."
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"PD-1 blockade increased the expression of (64 of 84 genes,> 2-fold increase) the majority of NFkB target genes in DCs and this effect was higher than the up regulation of NFkB target genes observed in the DCs treated with LPS, the latter of which is consistent with prior findings that LPS induced activation of cytokine gene expression is suppressed in TIDCs as compared to bone marrow derived DCs (XREF_FIG)."
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"Importantly, the exposure of IEC-6 cells to Celastrol resulted not only in a marked increase in cytoplasmic Hsp70 expression (red staining in XREF_FIG) but also to a significant reduction in the extent of TLR4 signaling, as measured by a reduction in the extent of LPS induced apoptosis (XREF_FIG), a reduction in the extent of LPS induced NFkB translocation (XREF_FIG), and a significant reduction in the extent of LPS induced IL-6 expression (XREF_FIG)."
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"Focusing on the NFkappaB signaling cascade they found that 6-shogaol reduced both LPS activated p50 and p65 translocation from the cytosol into the nucleus as well as NFkappaB activation in a reporter gene assay using RAW 264.7 cells."
| PMC
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"LPS pretreatment completely blocked the nuclear localization of p50 induced by I/R injury, which can be reversed by knockdown of miR-146a."
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"Conclusively, the present study unveiled the protective role of the G. oblongata marine extract in LPS stimulated oxidative reaction, inflammation, and apoptosis by suppressing NFkb and ROS as well as PI3K and AKT pathways through inhibition of PTK, suggesting its promising role in attenuating inflammation as well as the liver injury (septic endotoxemia) which is a process that levels of blood LPS are elevated."
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"LPS treatment in presence of Heclin increased Nr4a1, Mapk8 and decreased Nfkb (Online Figure XIB)."
33508948
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"The obtained results suggest that SC and SG oils exert the anti-inflammatory effects in LPS stimulated RAW 264.7 cells by suppressing NF-KB activation."
30549613
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"Our findings indicate miR-150 predicts survival in patients with sepsis and inhibits LPS induced inflammatory factors and apoptosis by targeting NF-kappaB1 in human umbilical vein endothelial cells."
29689269
eidos
"Both IV and intratracheal ( IT ) administration of mesenchymal stem cell-extracellular vesicles ( MSC-EVs ) alleviate lipopolysaccharide ( LPS ) - induced lung injury , elevate miR-27a-3p levels , and decrease NFKB1 levels ."
35046923
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"Whereas in the presence of exogenously applied cell-permeable cGMP the IRAK3 mutant was able to retain its function by suppressing lipopolysaccharide induced NFkB activity."
31664109
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"The fact that lithium potently potentiated and greatly prolonged LPS stimulated p105 degradation suggests the existence of additional mechanisms."
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"Recent studies demonstrate that the NF-kappaB1 precursor protein p105 functions as an inhibitor of Tpl2 and that the LPS stimulated Tpl2 activation requires p105 degradation."
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"Our results showed that LPS treatment caused the decrease of p65 and p50 in the cytoplasm and increase in nucleus, and this effect can be reversed by the pretreatment with WEL in a dose dependent manner."
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"LPS stimulated p105 degradation is mediated through phosphorylation of p105 by IKKbeta [XREF_BIBR, XREF_BIBR]."
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"However, MyD88 dependent activation of NFkB can also be induced by TAK1 independent pathways, as reported in TAK1 deficient murine embryonic fibroblasts, where incomplete suppression of IL1R or LPS induced NFkB activation was observed [XREF_BIBR]."
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"This was associated with a reduction of LPS-induced NF-KB binding activity."
| PMC
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"Furthermore, inhibition of cytokine production by 17 beta-estradiol was associated with a decreased LPS induced NFkB binding activity."
9266010
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"MicroRNA-322 inhibits inflammatory cytokine expression and promotes cell proliferation in LPS stimulated murine macrophages by targeting NF-kappaB1 (p50)."
27986864
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"Since both IFNgamma and LPS are known to activate NFkB, we determined whether LPS induced activation of NFkB is suppressed by netrin-1 in a macrophage cell line."
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"In LSEC, pre-treatment with BMP-9 reduced the LPS mediated activation of the NfkB pathway, whereas in macrophages, LPS partially inhibited the BMP-9 and Smad-1 signaling cascade."
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"Lipopolysaccharide induced NFkB activity was not suppressed in cells transfected with the IRAK3 mutant with reduced cGMP-generating capacity."
31664109
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"PGE 2 suppresses LPS induced degradation of p105."
19531803
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"In the present study, an extract from stem bark of Cinnamomum cassia Blume (Lauraceae) was discovered to have an inhibitory effect on LPS induced NF-KB transcriptional activity, which was determined using macrophages RAW 264.7 transfected stably with an alkaline phosphatase reporter construct containing four copies of the NF-KB binding KB sequence."
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"In mutant pre-B cells lacking IKKgamma, processing was unaffected, but LPS induced p105 degradation was abolished."
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"(B) InhIbItIOn of LPS induced NF-KB actIvatIOn by herbImycin A. C6 cells were pretreated for 12 h with herbimycIn A at the indicated concentratIOns followed by InCUbatIOn with 10, ug/ml LPS for I h. T[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7556623
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"Baer et al. (1998) reported that LPS stimulation in macrophages promotes hyper-induction of p50 and TNFalpha gene repression."
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"Whereas in the presence of exogenously applied cell-permeable cGMP the IRAK3 mutant was able to retain its function by suppressing lipopolysaccharide induced NFkB activity."
31664109
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"MicroRNA-322 inhibits inflammatory cytokine expression and promotes cell proliferation in LPS stimulated murine macrophages by targeting NF-kappaB1 (p50)."
27986864
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"Reduced cell division and increased apoptosis of LPS stimulated nfkb1 -/- B cells was also shown not to be influenced by the presence of normal cells (Grumont, R.J., results not shown)."
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"P53 inhibition in CAIA and LPS treated PARK2 KO mice increased p50 and p65 nuclear localization and NF-kappaB activation."
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"As shown in XREF_FIG C, the single and lower dose of LPS (10 ng/mL) did not trigger a considerable enrichment of p50 at the promoter of TNF-alpha."
33671709
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"MiR-150 predicts survival in patients with sepsis and inhibits LPS induced inflammatory factors and apoptosis by targeting NF-kappaB1 in human umbilical vein endothelial cells."
29689269
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"Using Western immunodetection of the NF kappa B1 p50 subunit, we also show that AraLAM and LPS stimulate the loss of the NF kappa B1 p105 precursor."
7729908
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"Inhibition of the LPS induced NF-KB binding activity in nuclear extract of splenocytes by AAF."
8625282
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"Recently Oliver et al., [XREF_BIBR] have shown in 3T3-L1 adipocytes and in macrophages that DHA has greater anti-inflammatory effect compared to EPA by attenuating the LPS induced NFkB activation and TNF-alpha secretion."
23259689
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"Genes associated with pathways involved in fatty acid metabolism, LPS and IL-1-mediated inhibition of RXR function, NFkB signaling pathway and oxidative stress were highly impacted by SLD and LPS cotreatment."
20371263
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"10 MiR-322 inhibits inflammatory cytokine expression in LPS stimulated murine macrophages by targeting NF-kappaB1."
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"The addition of LPS (100 ng/mL, 15 min) significantly increased and decreased the nuclear content of p50 and RelA and p50 and p50, respectively (XREF_FIG)."
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