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Lipopolysaccharide inhibits NFKB1. 57 / 57
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"We next investigated the effect of MTOR inhibition on LPS induced activation of NFKB."
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"Furthermore, Liu et al. [39] found that RSV reduced microglial overactivation and increased neurogenesis in the subgranular zone while decreasing NFkB in the animal model of depression induced by LPS."
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"This was associated with a reduction of LPS-induced NF-KB binding activity."
| PMC
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"Focusing on the NFkappaB signaling cascade they found that 6-shogaol reduced both LPS activated p50 and p65 translocation from the cytosol into the nucleus as well as NFkappaB activation in a reporter gene assay using RAW 264.7 cells."
| PMC
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"PD-1 blockade increased the expression of (64 of 84 genes,> 2-fold increase) the majority of NFkB target genes in DCs and this effect was higher than the up regulation of NFkB target genes observed in the DCs treated with LPS, the latter of which is consistent with prior findings that LPS induced activation of cytokine gene expression is suppressed in TIDCs as compared to bone marrow derived DCs (XREF_FIG)."
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"However, MyD88 dependent activation of NFkB can also be induced by TAK1 independent pathways, as reported in TAK1 deficient murine embryonic fibroblasts, where incomplete suppression of IL1R or LPS induced NFkB activation was observed [XREF_BIBR]."
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"Several previous studies reported that overexpression of Tollip causes inhibition of LPS induced NFkB activation ( Bulut et al., 2001; Burns et al., 2000; Zhang and Ghosh, 2002 )."
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"Moreover, the extract exhibited inhibitory activity on LPS-induced p50 mRNA synthesis, further supporting its anti-inflammatory properties (Matsui et al., 2012)."
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"NNU-hdpa inhibits, in a concentration-dependent manner (0.1 to 10 µM), the nuclear translocation of the NF-κB p50 subunit: at the highest 10 µM concentration, LPS-induced p50 translocation is inhibite[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Second, Tollip inhibits LPS-mediated NFkB activation, while Tollip K150E mutant has no effect."
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"Co-incubation of LPS and PDTC prevented upregulation of NFKB-regulated genes Tnf , Il1b and Nfkbia ( Fig. 2 A), confirming the functionality of TLR4/NFKB signaling in WD and its responsiveness to LPS."
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"For those receiving HS pretreatment, the LPS-induced nuclear p50 elevation was only noticed in after recovery groups, but not in before and after UW groups, suggesting that heat preconditioning only c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, mutation of Tollip lysine150 to glutamic acid abolishes its lipid binding capability as well as its inhibitory effect on LPS-induced NFkB activation."
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"Both IV and intratracheal ( IT ) administration of mesenchymal stem cell-extracellular vesicles ( MSC-EVs ) alleviate lipopolysaccharide ( LPS ) - induced lung injury , elevate miR-27a-3p levels , and decrease NFKB1 levels ."
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"10 MiR-322 inhibits inflammatory cytokine expression in LPS stimulated murine macrophages by targeting NF-kappaB1."
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"LPS pretreatment completely blocked the nuclear localization of p50 induced by I/R injury, which can be reversed by knockdown of miR-146a."
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"In the present study, an extract from stem bark of Cinnamomum cassia Blume (Lauraceae) was discovered to have an inhibitory effect on LPS induced NF-KB transcriptional activity, which was determined using macrophages RAW 264.7 transfected stably with an alkaline phosphatase reporter construct containing four copies of the NF-KB binding KB sequence."
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"Wasabi extracts cocultured with LPS-treated macrophages and Caco-2 cells inhibited NFkB, decreased IL1β and IFN-γ concentrations, and increased the expression of tight junction proteins zonula occludens-1 (ZO-1) and claudin, but not occludin, in Caco-2 cells [125]."
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"Reduced cell division and increased apoptosis of LPS stimulated nfkb1 -/- B cells was also shown not to be influenced by the presence of normal cells (Grumont, R.J., results not shown)."
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"Since both IFNgamma and LPS are known to activate NFkB, we determined whether LPS induced activation of NFkB is suppressed by netrin-1 in a macrophage cell line."
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"LPS mediated NF-KB activation was inhibited by NAC and a-TOC at all concentrations tested."
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"Our results showed that LPS treatment caused the decrease of p65 and p50 in the cytoplasm and increase in nucleus, and this effect can be reversed by the pretreatment with WEL in a dose dependent manner."
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"LPS mediated NF-KB activation was suppressed by all drug concentrations tested.To determine whether antioxidant mediated inhibition of NF-KB activation is accompanied by suppression of LPS induced cytokine production by Kupffer cells, we measured the effect of NAC and ot-TOC on TNF-oL secretion."
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"Moreover, parasite ligands treated cells also displayed reduction in LPS induced NFkB activation ( Chauhan et al., 2014 )."
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"Furthermore, inhibition of cytokine production by 17 beta-estradiol was associated with a decreased LPS induced NFkB binding activity."
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"PGE 2 suppresses LPS induced degradation of p105."
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"Baer et al. (1998) reported that LPS stimulation in macrophages promotes hyper-induction of p50 and TNFalpha gene repression."
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"We observed significantly diminished LPS induced NF-kappaB p50 and p65 dimer translocation in the cells pretreated with 10mM metformin."
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"P53 inhibition in CAIA and LPS treated PARK2 KO mice increased p50 and p65 nuclear localization and NF-kappaB activation."
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"The obtained results suggest that SC and SG oils exert the anti-inflammatory effects in LPS stimulated RAW 264.7 cells by suppressing NF-KB activation."
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"In mutant pre-B cells lacking IKKgamma, processing was unaffected, but LPS induced p105 degradation was abolished."
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"One of the key TFs involved in this process, both in human and murine macrophages is ATF3, a TF that has been previously linked to a negative feedback loop of LPS-induced NFkB-mediated macrophage acti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The LPS-free control and treatment with the LPS at 10 ng/mL reduced mRNA abundance of Nfkb1 at pH 6.0 only (P = 0.04, Figure 1, panel C)."
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"MicroRNA-322 inhibits inflammatory cytokine expression and promotes cell proliferation in LPS stimulated murine macrophages by targeting NF-kappaB1 (p50)."
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"In this study, we demonstrated that miR-31 was a negative regulator in LPS-induced expression of immune responses by targeting NF-κB1 ( p105 ) in sea cucumber coelomocytes."
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"Genes associated with pathways involved in fatty acid metabolism, LPS and IL-1-mediated inhibition of RXR function, NFkB signaling pathway and oxidative stress were highly impacted by SLD and LPS cotreatment."
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"In LSEC, pre-treatment with BMP-9 reduced the LPS mediated activation of the NfkB pathway, whereas in macrophages, LPS partially inhibited the BMP-9 and Smad-1 signaling cascade."
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"Melittin treatment in arthritis decreases LPS-induced p50 redistribution into the nucleus, lowering inflammatory gene expression (Zhang et al., 2024)."
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"Additionally, it decreased the expression of LPS-induced p-IKKbeta and p-NF-kappaB p65 and prevented the migration of p-NF-kappaB into the nucleus caused by LPS."
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"LPS treatment in presence of Heclin increased Nr4a1, Mapk8 and decreased Nfkb (Online Figure XIB)."
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"Using Western immunodetection of the NF kappa B1 p50 subunit, we also show that AraLAM and LPS stimulate the loss of the NF kappa B1 p105 precursor."
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"Lipopolysaccharide induced NFkB activity was not suppressed in cells transfected with the IRAK3 mutant with reduced cGMP-generating capacity."
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"Whereas in the presence of exogenously applied cell-permeable cGMP the IRAK3 mutant was able to retain its function by suppressing lipopolysaccharide induced NFkB activity."
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"LPS stimulated p105 degradation is mediated through phosphorylation of p105 by IKKbeta [XREF_BIBR, XREF_BIBR]."
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"The fact that lithium potently potentiated and greatly prolonged LPS stimulated p105 degradation suggests the existence of additional mechanisms."
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"The addition of LPS (100 ng/mL, 15 min) significantly increased and decreased the nuclear content of p50 and RelA and p50 and p50, respectively (XREF_FIG)."
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"Conclusively, the present study unveiled the protective role of the G. oblongata marine extract in LPS stimulated oxidative reaction, inflammation, and apoptosis by suppressing NFkb and ROS as well as PI3K and AKT pathways through inhibition of PTK, suggesting its promising role in attenuating inflammation as well as the liver injury (septic endotoxemia) which is a process that levels of blood LPS are elevated."
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"(B) InhIbItIOn of LPS induced NF-KB actIvatIOn by herbImycin A. C6 cells were pretreated for 12 h with herbimycIn A at the indicated concentratIOns followed by InCUbatIOn with 10, ug/ml LPS for I h. T[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In studies conducted on the BV2 cell line, EGCG was able to ameliorate the LPS (lipopolysaccharide)-induced microglia activation by decreasing the TLR4/NFkB (toll-like receptor 4/nuclear factor kappa B)-dependent inflammasome activation [22]."
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"In studies conducted on the BV2 cell line, EGCG was able to ameliorate the LPS (lipopolysaccharide)-induced microglia activation by decreasing the TLR4/NFkB (toll-like receptor 4/nuclear factor kappa B)-dependent inflammasome activation [22]."
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"Recently Oliver et al., [XREF_BIBR] have shown in 3T3-L1 adipocytes and in macrophages that DHA has greater anti-inflammatory effect compared to EPA by attenuating the LPS induced NFkB activation and TNF-alpha secretion."
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"As shown in Fig. 5 A, LPS dramatically stimulated p50 and p65 DNA-binding activity, while LPS-activated p50 and p65 were significantly impaired by Mar M."
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"However, it has been reported that Lithium attenuated LPS-induced activated TLR4 signaling in macrophages through induces degradation of the NF-κB precursor protein, p105, leading to persistent activa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"More recently, mutations in the Tpl2 catalytic loop which influence its p105 binding affinity were found to affect the rate of LPS-induced p105 degradation [61] ."
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"Inhibition of the LPS induced NF-KB binding activity in nuclear extract of splenocytes by AAF."
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"As shown in XREF_FIG C, the single and lower dose of LPS (10 ng/mL) did not trigger a considerable enrichment of p50 at the promoter of TNF-alpha."
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"Importantly, the exposure of IEC-6 cells to Celastrol resulted not only in a marked increase in cytoplasmic Hsp70 expression (red staining in XREF_FIG) but also to a significant reduction in the extent of TLR4 signaling, as measured by a reduction in the extent of LPS induced apoptosis (XREF_FIG), a reduction in the extent of LPS induced NFkB translocation (XREF_FIG), and a significant reduction in the extent of LPS induced IL-6 expression (XREF_FIG)."
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