IndraLab

Statements

USP8 activates corticotropin secretion. 3 / 3
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"Ma et al. showed that USP8 knockdown attenuated ACTH secretion in primary USP8-mutated tumor cells [266]."
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"The potential of USP8 as a therapeutic target was also suggested, as inhibitors of USP8 were shown to decrease cell proliferation and ACTH secretion in mouse corticotropinoma‐derived AtT‐20 cells [52]."
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"Gain-of-function USP8 somatic mutations in corticotropinomas increase its deubiquitinating effect and thus overall EGFR signaling activation, leading to enhanced proopiomelanocortin (POMC) expression and ACTH secretion."
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