IndraLab

Statements

BAP1 inhibits FOXO3. 3 / 3
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"This indicated that the increase in BAP1 after SAH could significantly reduce the degradation of FOXO3a protein for increasing the stability of FOXO3a protein, and inhibiting BAP1 can promote the degradation of FOXO3a protein."
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"Furthermore, BAP1 protein appears to inhibit FOXO3a degradation via the proteasome-dependent pathway, thereby preserving the activity and stability of the FOXO3a protein."
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"After transfection of Flag-FOXO3a, HA-BAP1 and various ubiquitin mutants (K48, K63, K48R and K63R) into 293T cells, it was observed that BAP1 predominantly reduced the ubiquitin modification of the FOXO3a protein at the K48 position, thereby verified the experimental findings regarding the half-life of FOXO3a."
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