IndraLab

Statements

USP28 activates CLSPN. 4 / 4
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"These results suggest that USP28 specifically enhances Claspin protein stabilization through a de-ubiquitination event."
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"The specificity of DUBs, however, is poorly understood, and it is currently unknown how Usp28 targets Claspin but not Plk1."
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"Additionally, in this system, USP28 only targets Claspin but not PLK1 (both of which are subject to ubiquitination by the same E3 ligase)."
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"In conclusion, when faced with DNA damage, HNF-1beta-overexpressing cells conferred them with cell survival activity that is mediated through the USP28 mediated Claspin stabilization and then persistent Chk1 activation."
29707125