IndraLab

Statements

USP28 activates CLSPN. 5 / 5
| 5
reach
"In conclusion, when faced with DNA damage, HNF-1beta-overexpressing cells conferred them with cell survival activity that is mediated through the USP28 mediated Claspin stabilization and then persistent Chk1 activation."
29707125
reach
"USP28 has been reported to promote the proliferation of both tumor and normal cells by stabilizing Claspin [41]."
38076191
reach
"The specificity of DUBs, however, is poorly understood, and it is currently unknown how Usp28 targets Claspin but not Plk1."
18662541
reach
"These results suggest that USP28 specifically enhances Claspin protein stabilization through a de-ubiquitination event."
29707125
reach
"Additionally, in this system, USP28 only targets Claspin but not PLK1 (both of which are subject to ubiquitination by the same E3 ligase)."
29415985