IndraLab

Statements

USP15 activates CGAS. 2 / 2
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"USP15 activates cGAS in the presence of DNA by two parallel pathways: facilitating cGAS deubiquitination and enhancing its phase separation, which contrasts with conventional cGAS deubiquitination mechanisms, such as those mediated by USP14 ( xref , xref )."
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"In innate immunity, the cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING)pathway, a core DNA sensing mechanism, undergoes multi-level regulation by USP15 deubiquitination: USP15 activates cGAS via deubiquitination and feeds back positively to promote its dimerization and phase separation."
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