IndraLab

Statements

USP47 activates CTNNB1. 6 / 6
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"Additionally, chemical inhibition of USP47 reduced the expressions of several EMT markers, including CDH1, CTNNB1, and SNAIL, and reversed the morphological changes in MCF-10A cells undergoing EMT (Silvestrini et al., 2020)."
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"CAMP activates β-catenin activation via several mechanisms, including USP47 and Akt/PI3K signaling proteins.Besides Wnt/β-catenin and Akt/PI3K signaling, YAP and TAZ are the well-known crucial downstream proteins and transcription activators in the Hippo pathway, which regulates cell proliferation, renewal, and differentiation."
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"GSK-3beta inactivated by its upstream Akt and ubiquitin-specific protease 47 (USP47) has been shown to inhibit beta-catenin degradation."
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"Consistent with this result , we found that knockdown of USP47 detectably reduced the amount of beta-catenin ( Fig. 3A , S5A ) ."
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"The results indicate that USP47 induces a positive process in Wnt and beta-catenin signaling while increasing the stability of beta-catenin [XREF_BIBR, XREF_BIBR]."
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"In addition, USP47 deubiquitinates itself and positively regulates β-catenin stabilization [173]."
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