IndraLab

Statements

USP47 activates CTNNB1. 3 / 3
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"Additionally, chemical inhibition of USP47 reduced the expressions of several EMT markers, including CDH1, CTNNB1, and SNAIL, and reversed the morphological changes in MCF-10A cells undergoing EMT (Silvestrini et al., 2020)."
34604226
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"The results indicate that USP47 induces a positive process in Wnt and beta-catenin signaling while increasing the stability of beta-catenin [XREF_BIBR, XREF_BIBR]."
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"GSK-3β inactivated by its upstream Akt and ubiquitin-specific protease 47 (USP47) has been shown to inhibit β-catenin degradation."
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